Application of whole-exome sequencing for detecting copy number variants in CMT1A/HNPP
Hye-Yeong Jo et al.,. (2016). "Application of whole-exome sequencing for detecting copy number variants in CMT1A/HNPP." Journal 1. 1(2).
CV
Education
- B.S in Mathematics, 2010
- B.S in Biotechnology, 2010
- M.S in Biochemistry, 2012
- Ph.D in Bioinformatics, Seoul National University, 2021
- Supervisor: Professor Sun Kim
Professional Research Experiences
- Korea National Institute of Health (December 2020 - Present) Senior Manager, Division of Healthcare and Artificial Intelligence, Republic of Korea
- Leading a project to collect and analyze large-scale clinical and multi-omics datasets from COVID-19 patients
- Leading research projects to understand brain tumor and colorectal cancers with single cell omics data including spatial transcriptomics.
- Leading research project to predict risk prediction using heterogeneous healthcare dataset.
- Setting up the pipelines of deep learning algorithms for healthcare and biomedicine data
- Korea National Institute of Health (April 2014 - December 2020) Researcher, Division of Intractable Diseases Research, Republic of Korea
- Setting up the pipelines for next-generation sequencing (NGS) data, including Whole-genome sequencing(WGS), SNP chip, bulk RNA-seq, Targeted Bisulfite-seq, ChIP-seq, and ATACseq.
- Multi-omics integration and network modeling of genetic and epigenetic data
- Standardization of genetic quality control testing to reveal genomic stability human pluripotent stem cells for biobanking
- Chonnam National University (September 2012 - August 2013) Research Assistant, Republic of Korea
- Instructing of molecular experiments to undergraduate students
- Molecular experiments in Biochemistry (antibodies/protein work)
Skills
- Technical Skills
Programming languages Python and R for statistical modeling, data visualization, and bioinformatic pipeline development Database SQL for querying and managing clinical and genomic data repositories Operating system Linux and Unix Bash Shell for high-throughput data processing
- Molecular Experiments in Laboratory
Biochemistry Protein isolation, purification, and analysis (including HPLC, LC, LC-MS/MS) Molecular Biology DNA/RNA extraction, PCR, cloning, and gene expression analysis Microbiology Cell culture techniques and microbial manipulation
- Language
- Korean (Native)
- English (Profient)
Publications
Optimized detection of insertions/deletions (INDELs) in whole-exome sequencing data
Bo-Young Kim et al., (2017). "Optimized detection of insertions/deletions (INDELs) in whole-exome sequencing data." PLoS One1. 12(8).
Genetic analysis of parathyroid and pancreatic tumors in a patient with multiple endocrine neoplasia type 1 using whole-exome sequencing
Bo-Young Kim et al., (2017). "Genetic analysis of parathyroid and pancreatic tumors in a patient with multiple endocrine neoplasia type 1 using whole-exome sequencing." BMC Medical Genetics. 18(1):106.
Peroxide-dependent oxidation reactions catalyzed by CYP191A1 from Mycobacterium smegmatis
H-Y Jo et al.,. (2017). "Peroxide-dependent oxidation reactions catalyzed by CYP191A1 from Mycobacterium smegmatis." Biotechnology Letters. 1(2).
Drug Discovery Platform Targeting M. tuberculosis with Human Embryonic Stem Cell-Derived Macrophages
Hye-Yeong Jo et al.,. (2019). "Drug Discovery Platform Targeting M. tuberculosis with Human Embryonic Stem Cell-Derived Macrophages." Stem Cell Reports. 13(6):980-991.
Simple differentiation method using FBS identifies DUSP6 as a marker for fine-tuning of FGF-ERK signaling activity in human pluripotent stem cells
DH Yoo et al.,. (2020). "Simple differentiation method using FBS identifies DUSP6 as a marker for fine-tuning of FGF-ERK signaling activity in human pluripotent stem cells." Biochem Biophys Res Commun. 521(2):375-382.
Development of genetic quality tests for good manufacturing practice-compliant induced pluripotent stem cells and their derivatives
Hye-Yeong Jo et al.,. (2020). "Development of genetic quality tests for good manufacturing practice-compliant induced pluripotent stem cells and their derivatives." Scientific Reports. 10(1):3939.
Functional in vivo and in vitro effects of 20q11.21 genetic aberrations on hPSC differentiation
Hye-Yeong Jo et al.,. (2020). "Functional in vivo and in vitro effects of 20q11.21 genetic aberrations on hPSC differentiation." Stem Cell Reports. 10(1):18582.
Korea National Stem Cell Bank
Jung-Hyun Kim et al.,. (2021). "Korea National Stem Cell Bank." Stem Cell Research. 53:102270.
Single-Cell RNA Sequencing of Human Pluripotent Stem Cell-Derived Macrophages for Quality Control of The Cell Therapy Product
Hye-Yeong Jo et al.,. (2022). "Single-Cell RNA Sequencing of Human Pluripotent Stem Cell-Derived Macrophages for Quality Control of The Cell Therapy Product." Frontiers in Genetics. 12:658862.
Establishment of the large-scale longitudinal multi-omics dataset in COVID-19 patients: data profile and biospecimen
Hye-Yeong Jo et al., (2022). "Establishment of the large-scale longitudinal multi-omics dataset in COVID-19 patients: data profile and biospecimen." Stem Cell Reports. 55(9):465-471.
Elevated IFNA1 and suppressed IL12p40 associated with persistent hyperinflammation in COVID-19 pneumonia
Kyeongseok Jeon et al.,. (2023). "Elevated IFNA1 and suppressed IL12p40 associated with persistent hyperinflammation in COVID-19 pneumonia." Frontiers in Immunology. 14:1101808.